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王源超

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王源超 老师


个人简历

王源超,山东荣成市人。植物病理学教授。

长江学者特聘教授(2011)、国家杰出青年基金获得者(2012)。

19967月毕业于南京农业大学植保系获得博士学位,1996-1999年在浙江大学生物技术研究所从事博士后研究。现为国际卵菌分子遗传委员会(OMGN)执行委员,中国植物病理学会卵菌病害专业委员会主任,国家大豆产业技术体系病虫害研究室主任。PLoS PathogensMPMIMPP9种学术刊物的编委。5次担任国际学术会议主席,在MPMI等重要国际学术会议以及康奈尔大学、俄勒冈州立大学和瓦赫宁根大学等国内外著名学术机构进行特邀报告30余次。以通讯作者在SciencePlant CellNature CommunicationsCurrent BiologyPLoS Pathogens等发表论文130多篇。获得教育部自然科学一等奖、教育部科技进步一等奖1项等省部级奖项5项。

长期从事作物疫病的成灾机理以及病害控制的新技术研究。主要学术成就:(1)鉴定了一类新的疫霉菌胞外效应子XEG1,发现其在胞外与植物蛋白抑制子互用的分子机制,提出了病原菌攻击寄主的诱饵模式Science, 2017);(2)建立了卵菌无毒基因鉴定的新策略,鉴定了8个大豆疫霉新无毒基因,分析了其在中国群体的变异方式,系统阐明了疫霉菌毒性变异的分子机制;(3)发现疫霉菌RxLR效应子可以相互协作,以模拟植物抗病抑制子、利用植物蛋白构象加工系统、调控植物内质网压力、干扰植物的组蛋白乙酰化等方式干扰植物的抗病性;(4)发现了大豆疫霉通过G蛋白信号系统调控对大豆根系分泌物异黄酮的识别从而寻找寄主植物,澄清了疫霉菌对寄主识别的分子机理;(5)发掘了一批新的病原菌快速监测的分子靶标,建立了十余种病原菌的快速检测技术,形成多项国家和行业标准,并得到广泛推广应用。

先后承担本科生《农业植物病理学》、《普通植物病理学》、《植物病害诊断》和研究生《真菌学》和《病原生物分子遗传学》等课程,参编教材或著作6本。先后被评为南京农业大学优秀研究生导师(2010)和优秀教师(2010)。

 

研究方向

1. 疫霉菌致病与变异的分子基础

2. 作物对疫病菌持久抗性的分子基础与应用

3. 大豆真菌病害的发生规律与综合防控技术

4. 外来入侵生物学

 

研究课题

1. 国家公益性行业科技(农业)专项,作物疫病监测防控技术研究与示范(2013-2017

2. 中荷政府间国际科技合作JSTP项目,马铃薯和大豆疫病可持续防控新靶标发掘的合作研究(2013-2016

3. 国家大豆产业技术体系岗位科学家,大豆真菌病害(2007-2020

4. 国家杰出青年基金项目,植物病原卵菌(2013-2017

6. 国家自然科学基金重点项目,疫霉菌RxLR-Nudix类效应分子抑制植物免疫的分子机制(2015-2019

 

代表论著

1. Ma, Z., Zhu, L., Song, T., Wang, Y., Zhang, Q., Xia, Y., Qiu, M., Lin, Y., Li, H., Kong, L., Fang, Y., Ye, W., Dong, S., Zheng, X., Tyler, B.M., Wang, Y.* A paralogous decoy protects Phytophthora sojae apoplastic effector PsXEG1 from a host inhibitor. Science 2017, 355:710-714 (Research Article, Highlighted by Nature chemical biology; Featured by Trends in Plant science and Molecular Plant).

2. Kong, L., Qiu, X., Kang, J., Wang, Y., Chen, H., Huang, J., Qiu, M., Zhao, Y., Kong, G., Ma, Z., Wang, Y., Ye, W., Dong, S., Ma, W., Wang, Y.* A Phytophthora effector manipulates host histone acetylation and reprograms defense gene expression to promote infection. Current Biology 2017, 27(7):981-991.

3. Yang, B., Wang, Q., Jing, M., Guo, B., Wu, J., Wang, H., Wang, Y., Lin, L., Ye, W., Dong, S., Wang, Y.* Distinct regions of the Phytophthora essential effector Avh238 determine its function in cell death activation and plant immunity suppression. New Phytologist 2017, 214(1):361-375.

4. Baxter L, ..., Wang Y, ... , McDowell JM, Beynon J, Tyler BM*. Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome. Science 2010, 330:1549-1551.

5. Qiao Y, Liu L, Xiong Q, Flores C, Wong J, Shi J, Wang X, Liu X, Xiang Q, Jiang S, Zhang F, Wang Y, Judelson HS, Chen X, Ma W*. Oomycete pathogens encode RNA silencing suppressors. Nature Genetics 2013, 45:330-333.

6. Jing M, Guo B, Li H, Yang B, Wang H, Kong G, Zhao Y, Xu H, Wang Y, Ye W, Dong S, Qiao Y, Tyler BM, Ma W, Wang Y*. A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins. Nature Communations 2016, 7:11685.

7. Ma Z, Song T, Zhu L, Ye W, Wang Y, Shao Y, Dong S, Zhang Z, Dou D, Zheng X, Tyler BM, Wang Y*. A Phytophthora sojae glycoside hydrolase 12 protein is a major virulence factor during soybean infection and is recognized as a PAMP. Plant Cell 2015, 27:2057-2072.

8. Wang Q, Han C, Ferreira AO, Yu X, Ye W, Tripathy S, Kale SD, Gu B, Sheng Y, Sui Y, Wang X, Zhang Z, Cheng B, Dong S, Shan W, Zheng X, Dou D, Tyler BM, Wang Y*. Transcriptional programming and functional interactions within the Phytophthora sojae RXLR effector repertoire. Plant Cell 2011, 23:2064-2086 (Cover story).

9. Dou D, Kale SD, Wang X, Chen Y, Wang Q, Wang X, Jiang RH, Arredondo FD, Anderson RG, Thakur PB, McDowell JM, Wang Y, Tyler BM*. Conserved C-terminal motifs required for avirulence and suppression of cell death by Phytophthora sojae effector Avr1b. Plant Cell 2008, 20:1118-1133.

10. Kong G, Zhao Y, Jing M, Huang J, Yang J, Xia Y, Kong L, Ye W, Xiong Q, Qiao Y, Dong S, Ma W, Wang Y*. The activation of Phytophthora effector Avr3b by plant cyclophilin is required for the nudix hydrolase activity of Avr3b. PLoS Pathogens 2015, 11:e1005139.

11. Dong S, Yin W, Kong G, Yang X, Qutob D, Chen Q, Kale SD, Sui Y, Zhang Z, Dou D, Zheng X, Gijzen M, Tyler BM, Wang Y*. Phytophthora sojae avirulence effector Avr3b is a secreted NADH and ADP-ribose pyrophosphorylase that modulates plant immunity. PLoS Pathogens 2011, 7:e1002353.

12. Dong S*, Wang Y*. Nudix Effectors: a common weapon in the arsenal of plant pathogens. PLoS Pathogens 2016, 12(8):e1005704.

13. Song T, Ma Z, Shen D, Li Q, Li W, Su L, Ye T, Zhang M, Wang Y, Dou D*. An oomycete CRN effector reprograms expression of plant HSP genes by targeting their promoters. PLoS Pathogens 2015, 11(12): e1005348.

14. Dong Y, Li Y, Zhao M, Jing M, Liu X, Liu M, Guo X, Zhang X, Chen Y, Liu Y, Liu Y, Ye W, Zhang H, Wang Y, Zheng X, Wang P, Zhang Z*. Global genome and transcriptome analyses of Magnaporthe oryzae epidemic isolate 98-06 uncover novel effectors and pathogenicity-related genes, revealing gene gain and lose dynamics in genome evolution. PLoS Pathogens 2015, 11(4):e1004801.

15. Guo M, Chen Y, Du Y, Dong Y, Guo W, Zhai S, Zhang H, Dong S, Zhang Z*, Wang Y, Wang P, Zheng X. The bZIP transcription factor MoAP1 mediates the oxidative stress response and is critical for pathogenicity of the rice blast fungus Magnaporthe oryzae. PLoS Pathogens 2011, 7(2):e1001302.

16. Wong J, Gao L, Yang Y, Zhai J, Arikit S, Yu Y, Duan S, Chan V, Xiong Q, Yan J, Li S, Liu R, Wang Y, Tang G, Meyers BC, Chen X, Ma W*. Roles of small RNAs in soybean defense against Phytophthora sojae infection. Plant Journal 2014, 79(6):928-40.

17. Yu X, Tang J, Wang Q, Ye W, Tao K, Duan S, Lu C, Yang X, Dong S, Zheng X, Wang Y*. The RxLR effector Avh241 from Phytophthora sojae requires plasma membrane localization to induce plant cell death. New Phytologist 2012, 196:247-260.

18. Gan Y, Zhang L, Zhang Z*, Dong S, Li J, Wang Y*, Zheng X. The LCB2 subunit of the sphingolip biosynthesis enzyme serine palmitoyltransferase can function as an attenuator of the hypersensitive response and Bax-induced cell death. New Phytologist 2009, 181:127-146.

19. Liu T, Ye W, Ru Y, Yang X, Gu B, Tao K, Lu S, Dong S, Zheng X, Shan W, Wang Y, Dou D*. Two host cytoplasmic effectors are required for pathogenesis of Phytophthora sojae by suppression of host defenses. Plant Physiology 2011, 155:490-501.

20. Lu S, Chen L, Tao K, Sun N, Wu Y, Lu X, Wang Y, Dou D*. Intracellular and extracellular phosphatidylinositol 3-phosphate produced by Phytophthora species is important for infection. Molecular Plant 2013, 6(5):1592-604.

21. Sheng Y, Wang Y, Meijer HJ, Yang X, Hua C, Ye W, Tao K, Liu X, Govers F, Wang Y*. The heat shock transcription factor PsHSF1 of Phytophthora sojae is required for oxidative stress tolerance and detoxifying the plant oxidative burst. Environmental Microbiology 2015, 17:1351-1364.

22. Yang X, Zhao W, Hua C, Zheng X, Jing M, Li D, Govers F, Meijer HJ, Wang Y*. Chemotaxis and oospore formation in Phytophthora sojae are controlled by G-protein-coupled receptors with a phosphatidylinositol phosphate kinase domain. Molecular Microbiology 2013, 88:382-394.

23. Hua C, Meijer HJ, de Keijzer J, Zhao W, Wang Y, Govers F*. GK4, a G-protein-coupled receptor with a phosphatidylinositol phosphate kinase domain in Phytophthora infestans, is involved in sporangia development and virulence. Molecular Microbiology 2013, 88(2):352-70.

24. Ye W, Wang Y, Shen D, Li D, Pu T, Jiang Z, Zhang Z, Zheng X, Tyler BM, Wang Y*. Sequencing of the litchi downy blight pathogen reveals it is a Phytophthora species with downy mildew-like characteristics. Mol Plant Microbe Interact 2016, 29:573-583.

25. Xiong Q, Ye W, Choi D, Wong J, Qiao Y, Tao K, Wang Y*, Ma W*. Phytophthora suppressor of RNA silencing 2 is a conserved RxLR effector that promotes infection in soybean and Arabidopsis thaliana. Mol Plant Microbe Interact 2014, 27:1379-1389.

26. Yin W, Dong S, Zhai L, Lin Y, Zheng X, Wang Y*. The Phytophthora sojae Avr1d gene encodes an RxLR-dEER effector with presence and absence polymorphisms among pathogen strains. Mol Plant Microbe Interact 2013, 26:958-968.

27. Song T, Kale SD, Arredondo FD, Shen D, Su L, Liu L, Wu Y, Wang Y, Dou D, Tyler BM*. Two RxLR avirulence genes in Phytophthora sojae determine soybean Rps1k-mediated disease resistance. Mol Plant Microbe Interact 2013, 26(7):711-720

28. Dong S, Kong G, Qutob D, Yu X, Tang J, Kang J, Dai T, Wang H, Gijzen M, Wang Y*. The NLP toxin family in Phytophthora sojae includes rapidly evolving groups that lack necrosis-inducing activity. Mol Plant Microbe Interact 2012, 25:896-909.

29. Ye W, Wang X, Tao K, Lu Y, Dai T, Dong S, Dou D, Gijzen M, Wang Y*. Digital gene expression profiling of the Phytophthora sojae transcriptome. Mol Plant Microbe Interact 2011, 24:1530-1539.

30. Li A, Wang Y, Tao K, Dong S, Huang Q, Dai T, Zheng X, Wang Y*. PsSAK1, a stress-activated MAP kinase of Phytophthora sojae, is required for zoospore viability and infection of soybean. Mol Plant Microbe Interact 2010, 23:1022-1031.

31. Zhang X, Zhai C, Hua C, Qiu M, Hao Y, Nie P, Ye W, Wang Y*. PsHint1, associated with the G-protein alpha subunit PsGPA1, is required for the chemotaxis and pathogenicity of Phytophthora sojae. Mol Plant Pathol 2016, 20:16.

32. Gao J, Cao M, Ye W, Li H, Kong L, Zheng X, Wang Y*. PsMPK7, a stress-associated mitogen-activated protein kinase (MAPK) in Phytophthora sojae, is required for stress tolerance, reactive oxygenated species detoxification, cyst germination, sexual reproduction and infection of soybean. Mol Plant Pathol 2015, 16:61-70.

33. Cui L, Yin W, Dong S, Wang Y*. Analysis of polymorphism and transcription of the effector gene Avr1b in Phytophthora sojae isolates from China virulent to Rps1b. Mol Plant Pathol 2011, 13(2):114-122.

 

More publications (links in PubMed and ResearchGate):

https://www.ncbi.nlm.nih.gov/pubmed/?term=wang+yuanchao

https://www.researchgate.net/profile/Yuanchao_Wang2

 

联系方式:025-84399071Tel Emailwangyc@njau.edu.cn