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窦道龙

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窦道龙 老师

个人简历

   窦道龙, 江苏邳州人;博士,植物病理学教授。1973年1月出生于江苏邳州。西北农林科技大学本科、硕士,中国科学院植物研究所博士,2003-2008年美国弗吉尼亚理工大学博士后。2008年作为高层次人才被引进南京农业大学。现为南京农业大学植物保护学院教授和博士生导师。2016年获国家杰出青年科学基金资助。

主要学术成就:从事疫霉菌与植物互作和调控研究,近年来在疫霉菌效应子的鉴定、功能与作用机制解析以及抗病育种利用等方面取得了突出成绩。发现疫霉菌能经非典型分泌途径产生一类新型效应子,将其命名为非典型效应子,为动植物病原菌致病物质的一种新类型;解析了多个效应子的功能与作用机制,首次阐明真核病原菌中有寄主DNA活性效应子;系统研究了疫霉菌效应子向寄主细胞内的转运过程,提出并完善了一种效应子转运的新理论模型,并以此为基础发展了基于病原菌效应子转运与功能的作物抗病分子育种新技术。研究结果深化了对作物疫病菌致病成灾机理的认识水平,为相关病害的控制奠定了理论和材料基础。

   主持国家自然科学基金和国家转基因生物新品种培育重大专项等竞争性课题10余项。公开发表发表论文70余篇,论文被引用2000余次。授权中国和美国专利3项。多次应邀在国内外学术会议上进行报告。曾获得教育部自然科学一等奖(排名第二)、教育部“新世纪优秀人才”、江苏省“杰出青年基金”和中国科学报社“青年科学之星”等资助和奖励。


研究方向

1. 植物与疫霉互作的生物信息学;

2. 疫霉致病成灾的分子机理;

3. 植物抗疫霉病害的分子机制与抗病基因工程。

研究课题

1. 教育部“新世纪优秀人才支持计划”,植物与疫霉互作的基因组学(F200901),2009-2011,主持

2. 国家973计划子课题,外来大豆疫霉入侵的分子生态适应机制(2009CB119200),2009-2013,课题骨干

3. 教育部重点项目,大豆疫霉效应因子Avr4/6的功能解析及机制探讨(E200909),2009-2011,主持

4. 自然基金面上项目,大豆疫霉一种新型激发子的功能解析与机制探讨(30971889),2010-2012,主持

研究成果

论文发表与引用参考:

http://scholar.google.com/citations?user=K4zrArEAAAAJ&hl=en


2015


1.Zhang M, Li Q, Liu T, Liu L, Shen D, Zhu Y, Liu P, Zhou JM, Dou D. 2015, Two cytoplasmic effectors of Phytophthora sojae regulate plant cell death via interactions with plant catalases. Plant Physiology. 167(1):164-75

2.Rajput NA, Zhang M, Shen D, Liu T, Zhang Q, Ru Y, Sun P, Dou D. 2015, Overexpression of a Phytophthora cytoplasmic CRN effector confers resistance to disease, salinity and drought in Nicotiana benthamiana. Plant Cell Physiol. 2015 Nov 6. pii: pcv164.

3.Zhang M, Ahmed Rajput N, Shen D, Sun P, Zeng W, Liu T, Juma Mafurah J, Dou D. 2015, A Phytophthora sojae cytoplasmic effector mediates disease resistance and abiotic stress tolerance in Nicotiana benthamiana. Sci Rep. 5:10837

4.Mafurah JJ, Ma H, Zhang M, Xu J, He F, Ye T, Shen D, Chen Y, Rajput NA, Dou D. 2015, A Virulence Essential CRN Effector of Phytophthora capsici Suppresses Host Defense and Induces Cell Death in Plant Nucleus. PLoS One. 10(5):e0127965

5.Ma Z, Song T, Zhu L, Ye W, Wang Y, Shao Y, Dong S, Zhang Z, Dou D, Zheng X, Tyler BM, Wang Y. 2015, A Phytophthora sojae Glycoside Hydrolase 12 Protein Is a Major Virulence Factor during Soybean Infection and Is Recognized as a PAMP. Plant Cell. 27(7):2057-72.

6.Yin Z, Liu H, Li Z, Ke X, Dou D, Gao X, Song N, Dai Q, Wu Y, Xu JR, Kang Z, Huang L. 2015, Genome sequence of Valsa canker pathogens uncovers a potential adaptation of colonization of woody bark. New Phytol. 2015 208(4):1202-16.

7.柴春月,林艳玲,吴育人,沈丹宇,窦道龙, 2015, 大豆中疫霉诱导性GmDRRP基因启动子的克隆与功能分析, 《植物病理学报》



2014


1.Liu T, Song T, Zhang X, Yuan H, Su L, Li W, Xu J, Liu S, Chen L, Chen T, Zhang M, Gu L, Zhang B, Dou D. 2014, Unconventionally secreted effectors of two filamentous pathogens target plant salicylate biosynthesis. Nature Communications. 26;5:4686

2.Chen L, Shen D, Sun N, Xu J, Wang W, Dou D. 2014, Phytophthora sojae TatD nuclease positively regulates sporulation and negatively regulates pathogenesis. MPMI. 27(10):1070-80

3.Rajput NA, Zhang M, Ru Y, Liu T, Xu J, Liu L, Mafurah JJ, Dou D. 2014, Phytophthora sojae effector PsCRN70 suppresses plant defenses in Nicotiana benthamiana. PLoS One. 9(5): e98114

4.Yan Q, Cui X, Su L, Xu N, Guo N, Xing H, Dou D. 2014, GmSGT1 is differently required for soybean Rps genes-mediated and basal resistance to Phytophthora sojae. Plant Cell Rep. 33(8): 1275-88 

5.Guo N, Ye W, Yan Q, Huang J, Wu Y, Shen D, Gai J, Dou D, Xing H. 2014, Computational identification of novel microRNAs and targets in Glycine max. Mol Biol Rep. (8): 4965-75

6.卢晓雪,卢珊,马丽娜,张美祥,窦道龙,2014, NbRbohB基因在本氏烟与疫霉菌互作中的功能分析, 《植物保护学报》

7.李红娟,刘廷利,刘莉,张保龙,窦道龙,2014, 转棉花Gbve1基因拟南芥抗黄萎菌的细胞学机制分析, 《南京农业大学学报》


2013

1.Lu S, Chen L, Tao K, Sun N, Wu Y, Lu X, Wang Y, Dou D, Intracellular and extracellular phosphatidylinositol 3-phosphate produced by Phytophthora species are important for infection, Mol Plant, 2013, 6(5):1592-604

2.Chai C,  Lin Y,  Shen D,  Wu Y,  Li H,  Dou D, Identification and Functional Characterization of the Soybean GmaPPO12 Promoter Conferring Phytophthora sojae Induced Expression. PLoS ONE, 2013, 8(6): e67670.

3.Song T, Kale SD, Arredondo FD, Shen D, Su L, Liu L, Wu Y, Wang Y, Dou D, Tyler BM,Two RxLR avirulence genes in Phytophthora sojae determine soybean Rps1k-mediated disease resistance,MPMI, 2013, 26(7):711-20

4.Shen D, Liu T, Ye W, Liu L, Liu P, Wu Y, Wang Y, Dou D, Gene duplication and fragment recombination drive functional diversification of a superfamily of cytoplasmic effectors in Phytophthora sojae. PLoS ONE, 2013, 8(7): e70036

5.Tyler BM, Kale SD, Wang Q, Tao K, Clark HR, Drews K, Antignani V, Rumore A, Hayes T, Plett JM, Fudal I, Gu B, Chen Q, Affeldt KJ, Berthier E, Fischer GJ, Dou D, Shan W, Keller NP, Martin F, Rouxel T, Lawrence CB, Microbe-independent entry of oomycete RxLR effectors and fungal RxLR-like effectors into plant and animal cells is specific and reproducible, MPMI, 2013, 26(6):611-6


2012

1.Dou D, Zhou J, Phytopathogen effectors subverting host immunity: different foes, similar battleground, Cell Host Microbe, 2012, 12(4):484-95

2.Zhang B, Yang Y, Chen T, Yu W, Liu T, Li H, Fan X, Ren Y, Shen D, Liu L, Dou D, Chang Y, Island cotton Gbve1 gene encoding a receptor-like protein confers resistance to both defoliating and non-defoliating isolates of Verticillium dahliae, PLoS One. 2012;7(12):e51091

3.Nasir AR, Mumtaz AP, Dou D.2012, Shisham Dieback and its Possible Management: A Survey of Shisham Tree Disease in Pakistan, LAP LAMBERT Academic Publishing (专著)

4.刘廷利;茹艳艳;刘莉;刘沛菡;窦道龙,2012,大豆疫霉效应因子PsCRN115诱导烟草抗性的机制分析,南京农业大学学报,4:65-68

5.Chen B, Yu X, Ma Z, Dong S, Dou D, Wang Y, Zheng X. 2012. Phytophthora sojae effector Avh331 suppresses the plant defence response by disturbing the MAPK signalling pathway, PMPP, 77(1):1-9


2011

1.Liu T, Ye W, Ru Y, Yang X, Gu B, Tao K, Lu S, Dong S, Zheng X, Shan W, Wang Y, Dou D. 2011, Two host cytoplasmic effectors are required for pathogenesis of Phytophthora sojae by suppression of host defenses, Plant Physiology, 155: 490-501

2.Shen D, Ye W, Dong S, Wang Y, Dou D. 2011, Characterization of intronic structures and alternative splicing in Phytophthora sojae by comparative analysis of expressed sequence tags and genomic sequences, Canadian Journal of Microbiology, 57(2): 84-90

3.Guo N, Ye W, Wu X, Shen D, Wang Y, Xing H, Dou D, 2011, Microarray profiling reveals microRNAs involving soybean resistance to Phytophthora sojae, Genome, 54:1-5

4.Dong S, Yin W, Kong G, Yang X, Qutob D, Chen Q, Kale SD, Sui Y, Zhang Z, Dou D, Zheng X, Gijzen M, M Tyler B, Wang Y. 2011. Phytophthora sojae Avirulence Effector Avr3b is a Secreted NADH and ADP-ribose Pyrophosphorylase that Modulates Plant Immunity. PLoS Pathog. 7(11):e1002353

5.Wang Q, Han C, Ferreira AO, Yu X, Ye W, Tripathy S, Kale SD, Gu B, Sheng Y, Sui Y, Wang X, Zhang Z, Cheng B, Dong S, Shan W, Zheng X, Dou D, Tyler BM, Wang Y, 2011, Transcriptional Programming and Functional Interactions within the Phytophthora sojae RXLR Effector Repertoire, Plant Cell, 23(6):2064-2086

6.Ye W, Wang X, Tao K, Lu Y, Dai T, Dong S, Dou D, Gijzen M, Wang Y, 2011, Digital gene expression profiling of the Phytophthora sojae transcriptome, MPMI, 24(12):1530-9

7.Nasir AR, Mumtaz AP, Abdul ML, Dou D, Shahjahan R. 2011, Effect of neem (Azadirachta indica) products on seedling growth of shisham dieback, African Journal of Microbiology Research, 5:4937-4945


2010

1.Dou D, Kale SD, Liu T, Tang Q, Wang X, Arredondo F, Basnayake S, Whisson S, Drenth A, Maclean D, Tyler BM, 2010, Different domains of Phytophthora sojae effector Avr4/6 are recognized by soybean resistance genes Rps4 and Rps6, MPMI, 23(4):425-435

2.叶文武,王源超,窦道龙,2010, SeqHunter:序列搜索与分析的生物信息学软件包,生物信息学. 4:364-367,377

20.Kale SD, Gu B, Capelluto D, Dou D, Feldman E, Rumore A, Arredond F, Hanlon R, Fudal I, Rouxel T, Lawrence C, Shan W, Tyler BM, 2010, External Lipid PI3P Mediates Entry of Eukaryotic Pathogen Effectors into Plant and Animal Host Cells, Cell, 142 (2): 284-295 Erratum in: 142(6):981-983.

3.Wang Y, Li A, Wang X, Zhang X, Zhao W, Dou D, Zheng X, Wang Y., 2010, GPR11, a putative seven-transmembrane G protein coupled receptor, controls zoospore development and virulence of Phytophthora sojae. Eukaryot Cell, 9(2): 242 – 250


2009

1.Hua C, Wang Y, Zheng X, Dou D, Zhang Z, Govers F, Wang Y., 2009, A Phytophthora sojae G-protein alpha subunit is involved in chemotaxis to soybean isoflavones, Eukaryot Cell. 7(12):2133-40

2.Qutob D, Tedman-Jones J, Dong S, Kuflu K, Pham H, Wang Y, Dou D, Kale SD, Arredondo FD, Tyler BM, Gijzen M., 2009, Copy number variation and transcriptional polymorphisms of Phytophthora sojae RXLR effector genes Avr1a and Avr3a. PLoS One. 2009;4(4):e5066

3.Wang Y, Dou D, Wang X, Li A, Sheng Y, Hua C, Cheng B, Chen X, Zheng X, Wang Y., 2009, The PsCZF1 gene encoding a C2H2 zinc finger protein is required for growth, development and pathogenesis in Phytophthora sojae, Microb Pathog. 47(2):78-86


2008 and early

1.Dou D, Kale SD, Wang X, Jiang RH, Bruce NA, Arredondo FD, Zhang X, Tyler BM., 2008, RXLR-mediated entry of Phytophthora sojae effector Avr1b into soybean cells does not require pathogen encoded machinery, Plant Cell, 20(7):1930-1947

2.Dou D, Kale SD, Wang X, Chen Y, Wang Q, Wang X, Jiang RH, Arredondo FD, Anderson RG, Thakur PB, McDowell JM, Wang Y, Tyler BM., 2008, Conserved C-terminal motifs required for avirulence and suppression of cell death by Phytophthora sojae effector Avr1b, Plant Cell, 20(7):1118-1133

3.Tyler BM, Jiang RHY, Zhou L, Tripathy S, Dou D, Torto-Alalibo T, Li H, Mao Y, Liu B, Vega-Sanchez M, Mideros SX, Hanlon R, Smith BM, Krampis K, Ye K, Martin SS, Dorrance AE, Hoeschele I, Maroof MAS, 2008, Functional Genomics and Bioinformatics of the Phytophthora sojae Soybean Interaction. In "Genomics of Disease", J.P. Gustafson, ed. Springer (Book chapter)

4.Tyler BM, Dou D, Kale SD, Jiang RHY, Chen Y, Wang Q, Wang X, Arredondo FD, Wang Y, 2008, The effector repertoire of Phytophthora sojae: structure, function and evolution. In “Biology of Molecular Plant-Microbe Interactions”, Volume 6. Lorito M, Woo S, Scala F (eds), International Society for Molecular Plant-Microbe Interactions, St. Paul, Minnesota (Book chapter)

5.Tyler BM, Tripathy S, Zhang X, Dehal P, Jiang RH, Aerts A, Arredondo FD, Baxter L, Bensasson D, Beynon JL, Chapman J, Damasceno CM, Dorrance AE, Dou D, Dickerman AW, Dubchak IL, Garbelotto M, Gijzen M, Gordon SG, Govers F, Grunwald NJ, Huang W, Ivors KL, Jones RW, Kamoun S, Krampis K, Lamour KH, Lee MK, McDonald WH, Medina M, Meijer HJ, Nordberg EK, Maclean DJ, Ospina-Giraldo MD, Morris PF, Phuntumart V, Putnam NH, Rash S, Rose JK, Sakihama Y, Salamov AA, Savidor A, Scheuring CF, Smith BM, Sobral BW, Terry A, Torto-Alalibo TA, Win J, Xu Z, Zhang H, Grigoriev IV, Rokhsar DS, Boore JL., 2006, Phytophthora Genome Sequences Uncover Evolutionary Origins and Mechanisms of Pathogenesis, Science, 313(5791): 1261-1266

6.王旭静,窦道龙,王志兴,贾士荣,2006,海岛棉GbNPR1基因全长cDNA的克隆及其在烟草中的表达,中国农业科学,39(5):886-894

7.Dou D., Wang, B., Tang, Y., Wang Z., Sun J., 2003. Cloning and sequence analysis of a gene encoding polygalacturonase-inhibiting protein from cotton (Gossypium hirsutum), Progress in Natural Science. 13(2): 119-124


专利

1. Tyler BM, Dou D, Kale, SD, Gu B, 2010, Compositions and methods to protect cells by blocking entry of pathogen proteins, United States Patent (US20100093601);WO/2009/143133 (美国和国际专利)

获得荣誉

1.2008年教育部“新世纪优秀人才”

2.2011年中国科学报社“青年科学之星”

3.2012年江苏省“杰出青年基金”

联系方式

 025-84396973(Tel)  Email:ddou@njau.edu.cn