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叶永浩

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叶永浩 老师


个人简历

叶永浩,19791月生,江苏南京人,教授,博士生导师。

2001年本科毕业于南京大学基础学科教学强化部,2006年博士毕业于南京大学生命科学学院,同年进入南京农业大学植物保护学院工作至今。期间,2011年至2012年前往美国加州大学戴维斯分校进行合作研究。现主要从事天然产物结构与功能、新农药分子设计与合成方面的研究,先后主持国家自然科学基金、江苏省自然科学基金等课题,参加国家973、公益性行业专项等重大科研项目,已发表SCI论文40余篇,获授权国家发明专利4项。先后入选江苏省首批博士集聚计划2011)、江苏省高校青蓝工程中青年学术带头人(2016),获得南京农业大学首届大北农青年学者奖2016),指导研究生1人获江苏省优秀硕士学位论文。 

 

研究方向

天然产物农药及仿生合成;新农药分子设计与合成      

 

研究课题

主持课题:

1. 基于杀菌剂靶标酶FabH固定化亲和色谱的植物内生菌杀菌活性物质研究,国家自然科学基金面上项目,2016 - 2019

2. 基于SDH靶标的新型三唑酰胺类杀菌剂合成与构效关系研究,江苏省自然科学基金面上项目,2015 - 2018

3. 基于代谢组学技术的植物内生菌Nodulosporium sp. A21抗菌活性代谢产物研究,中央高校基本科研业务费重点项目,2015 - 2017

4. 基于固定化酶技术的植物内生菌杀虫活性物质研究,中央高校基本科研业务费重点项目,2011 -2013

5. 银杏内生菌杀虫、杀菌活性代谢产物研究,国家自然科学基金青年项目,2010 - 2012

6. 植物内生菌杀虫、杀菌活性代谢产物研究,高校博士点专项科研基金青年项目,2008 - 2010

7. 粘质沙雷氏菌XY21在番茄根围的定殖研究,江苏省自然科学基金青年项目,2007 - 2009

8. 微生物源具农药活性先导化合物的发现与优化,南京农业大学人才引进基金,2006 - 2008

主要参加项目:

1. 优质粳稻穗期重大病害致病机制及其绿色防控技术研究,江苏省农业科技自主创新资金重点项目,2015 - 2017

2. 农作物重要病原菌抗药性监测及治理技术研究与示范,公益性行业(农业)科研专项,2013 - 2017

3. 分子靶标导向的绿色化学农药创新研究,国家‘973’研究计划,2010 - 2014 

 

研究成果

5年发表论文(*通讯作者):

1. Wang X., Dai Z.C., Chen Y.F., Cao L.L., Yan W., Li S.K., Wang J.X., Zhang Z.G., Ye Y.H.* 2017. Synthesis of 1,2,3-triazole hydrazide derivatives exhibiting anti-phytopathogenic activity. European Journal of Medicinal Chemistry, 126 171-182.

2. Cao L.L., Zhang Y.Y., Liu Y.J., Yang T.T., Zhang J.L., Zhang Z.G., Shen L., Liu J.Y., Ye Y.H.* 2016. Anti-phytopathogenic activity of sporothriolide, a metabolite from endophyte Nodulisporium sp. A21 in Ginkgo biloba. Pesticide Biochemistry and Physiology, 129, 7-13.

3. Zhao Y.Y., Qian G.L., Ye Y. H., Wright S., Chen H.T., Shen Y.M., Liu F.Q., Du L.C. 2016. Heterocyclic aromatic Noxidation in the biosynthesis of phenazine antibiotics from Lysobacter antibioticus. Organic Letters, 18, 2495-2498.

4. Dai Z.C., Chen Y.F., Zhang M., Li S.K., Yang T.T., Shen L., Wang J.X., Qian S.S., Zhu H.L., Ye Y.H.* 2015. Synthesis and antifungal activity of 1,2,3-triazole phenylhydrazone derivatives. Organic & Biomolecular Chemistry, 13, 477-486.

5. Ye Y.H.*, Li C., Yang J., Ma L., Xiao Y., Hu J., Rajput N.A., Gao C.F.*, Zhang Y.Y., Wang M.H. 2015. Construction of immobilized-AChE column and its application in screening insecticidal constituents from Magnolia officinalis. Pest Management Science, 71, 607-615.

6. Zhang M., Dai Z.C., Qian S.S., Liu J.Y., Xiao Y., Lu A.M., Zhu H.L., Wang J.X., Ye Y.H.* 2014. Design, synthesis, antifungal and antioxidant activities of (E)-6-((2- phenylhydrazono)methyl)quinoxaline derivatives. Journal of Agricultural and Food Chemistry, 62, 6937-6943.

7. Ye Y.H.*, Ma L., Dai Z.C., Xiao Y., Zhang Y.Y., Li D.D., Wang J.X., Zhu H.L. 2014. Synthesis and antifungal activity of nicotinamide derivatives as succinate dehydrogenase inhibitors. Journal of Agricultural and Food Chemistry, 62, 4063-4071.

8. Wang L.L., Zhang Y.Y., Wang L., Liu F.Y., Cao L.L., Yang J., Qiao C.H.*, Ye Y.H.* 2014. Benzofurazan derivatives as fungicidal agents against phytopathogenic fungi. European Journal of Medicinal Chemistry, 80, 535-542.

9. Zhang D.Y., Ye Y.H., Li J. Dong L.Y. 2014. Allelopathic pathways, isolation and identification of an allelopathic substance from Solidago canadensis. Allelopathy Journal, 33, 201-212.

10. Hua X.D., Yin W., Shi H.Y., Li M., Wang Y.R., Wang H., Ye Y.H., Kim H.J., Gee S.J., Wang M.H., Liu F.Q., Hammock B.D. 2014. Development of phage immuno-loop-mediated isothermal amplification assays for organophosphorus pesticides in agro-products. Analytical Chemistry, 86, 8441-8447.

11. Ye Y.H.*, Xiao Y., Ma L., Li H.X., Xie Z.L., Wang M.H., Ma H.T., Tang H.W., Liu J.Y.* 2013. Flavipin in Chaetomium globosum CDW7, an endophytic fungus from Ginkgo biloba, contributes to antioxidant activity. Applied Microbiology and Biotechnology, 97, 7131-7139.

12. Li H.X., Xiao Y., Cao L.L., Yan X., Li C., Shi H.Y., Wang J.W., Ye Y.H.* 2013. Cerebroside C increases tolerance to chilling injury and alters lipid composition in wheat roots. PLoS One, 8, e73380.

13. Wang L.L., Li C., Zhang Y.Y., Qiao C.H.*, Ye Y.H.* 2013. Synthesis and biological evaluation of benzofuroxan derivatives as fungicides against phytopathogenic fungi. Journal of Agricultural and Food Chemistry, 61, 8632-8640.

14. Ma L., Xiao Y., Li C., Xie Z.L., Li D.D., Wang Y.T., Ma H.T., Zhu H.L., Wang M.H., Ye Y.H.* 2013. Synthesis and antioxidant activity of novel Mannich base of 1,3,4-oxadiazole derivatives possessing 1,4-benzodioxan. Bioorganic & Medicinal Chemistry, 21, 6763-6770.

15. Xiao Y., Li H.X., Li C., Wang J.X., Li J., Wang M.H., Ye Y.H.* 2013. Antifungal screening of endophytic fungi from Ginkgo biloba for discovery of potent anti-phytopathogenic fungicides. FEMS Microbiology Letters, 339, 130-136.

16. Zhang M., Lu X., Zhang H.J., Li N., Xiao Y., Zhu H.L., Ye Y.H.* 2013. Synthesis, structure, and biological assay of cinnamic amides as potential EGFR kinase inhibitors. Medicinal Chemistry Research, 22, 986-994.

17. Bogaerta I.V., Zhang G.D., Yang J., Liu J.Y., Ye Y.H., Soetaert W., Hammock B.D. 2013. Preparation of 20-HETE using multifunctional enzyme type 2 (MFE-2)-negative Starmerella bombicola. The Journal of Lipid Research, 54, 3215-3219.

18. Li J., Ye Y.H., Wang X.Y., Dong L.Y. 2012. Herbicidal activity of curvulinic acid isolated from Nimbya alternantherae. Natural Product Communications, 7, 51-52.

19. Li D.D., Lv P.C., Zhang H., Zhang H.J., Hou Y.P., Liu K., Ye Y.H.*, Zhu H.L.* 2011. The combination of 4-anilinoquinazoline and cinnamic acid: a novel mode of binding to the epidermal growth factor receptor tyrosine kinase. Bioorganic & Medicinal Chemistry, 19, 5012-5022.

20. Fu J., Zhou Y., Li H.F., Ye Y.H.*, Guo J.H.* 2011. Antifungal metabolites from Phomopsis sp. By254, an endophytic fungus in Gossypium hirsutum. African Journal of Microbiology Research, 5, 1231-1236.

21. Li J., Ye Y.H., Huang H.W., Dong L.Y. 2011. Kaempferol-3-O-β-D-glucoside, a potential allelochemical isolated from Solidago canadensis. Allelopathy Journal, 28, 259-266.

22. Shi H.Y., Zhang B.H., Ye Y.H., Zheng Z.T., Wang M.H. 2011. Development of an enzyme-linked immunosorbent assay for the pyrethroid fenpropathrin. Food and Agricultural Immunology, 22, 69-76.

 

授权国家发明专利:

1. 叶永浩, 马良, 李枞, . 含苯并1,4-噁二烷的1,3,4-噁二唑衍生物的制备方法及其用途. ZL201310116581.0

2. 叶永浩, 肖玉, 李红霞, . 一株球毛壳菌及其代谢产物黄柄曲菌素的制备和应用. ZL201210444164.4.

 

联系方式

Tel025-84399753Emailyeyh@njau.edu.cn